is lindane a severe marine pollutant

Electronic Code of Federal Regulations (e-CFR), Subtitle B - Other Regulations Relating to Transportation, CHAPTER I - PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION, SUBCHAPTER C - HAZARDOUS MATERIALS REGULATIONS, PART 172 - HAZARDOUS MATERIALS TABLE, SPECIAL PROVISIONS, HAZARDOUS MATERIALS COMMUNICATIONS, EMERGENCY RESPONSE INFORMATION, TRAINING REQUIREMENTS, AND SECURITY PLANS. Animal tests show that this substance possibly causes toxicity to human reproduction or development. [6] Most exposure of the general population to lindane results from agricultural uses and the intake of contaminated foods, such as produce, meats and milk. Column 1 is labeled S.M.P. for Severe Marine Pollutants and Column 2 is (1) On single packagings or combination packagings where each single package or each inner packaging of combination packagings has: (i) A net quantity of 5 L (1.3 gallons) or less for liquids; or, (ii) A net mass of 5 kg (11 pounds) or less for solids. For example, warfarin is used as a rodenticide to poison mice and rats (e.g., Kaput, D-Con) but is also formulated for medical use as an oral anticoagulant or "blood thinner" to treat patients with heart attacks, strokes and other clot-related disorders (e.g., Coumadin). Diarrhoea. Previous work showed that Microcystis aeruginosa PCC 7806 degrades lindane and that, in the presence of the pesticide, People who are occupationally exposed to it are advised to avoid its contact with eyes, skin and via inhalation. In addition, there were 46 hospitalizations, and seven life-threatening outcomesfive from the same household. [32][33] In the U.S., petitions to ban the use of pharmaceutical lindane have been rejected by the FDA and determined to be without merit by experts working with this regulatory agency. Sore throat. [5] However, in 2006, the Agency published an addendum to its initial decision and called for the voluntary cancellation of all agricultural uses by registered manufacturers (effective July 2007), citing a significant change in the costs and benefits of agricultural uses due to the recent introduction of seed-treatment alternatives to lindane. Headache. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. Refer for medical attention . Effects of long-term or repeated exposure Medical observation is indicated. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. The following ingredients are of concern in the marine environment and need more testing: Cinoxate. WebTherefore, if: (1) p-Dodecylphenol is a synonym to Dodecylphenol; and (2) the concentration of Dodecylphenol in the solution is at least one percent by weight, then the answer would be yes and "Lubrizol 9222R" would appear to be a marine pollutant. Refer immediately for medical attention. WebLindane is released into the environment during and after agricultural application through volatilization into the atmosphere (estimated at 12-30%), where it has long-range transport potential and can be deposited by rainfall. Lindane is categorized as a persistent organic pollutant, and its concentrated form persists in the aquatic environment. Physical State; Appearance Hepatic cytochrome P-450 oxygenase system. The substance may cause long-term effects in the aquatic environment. $>. People who are occupationally exposed to it are advised to avoid its Reacts with bases. [1] In 2003, the EPA reported on the results of large-scale water contaminant testing of 16,000 water systems serving 100 million people across the U.S. and found that none contained lindane levels above the maximum contaminant level standard considered safe. A review of the most serious cases described 15 deaths of which two were confirmed related to lindane misuse including a suicidal ingestion. That's what the Environmental Protection Agency said after downgrading ozone standards in the northern front range from "serious" to "severe." [27] Similar findings were noted by U.S. Geologic Survey teams in 1999 and 2000. Molecular mass: 290.8 Further see Ingestion. %%EOF [7] These infectious diseases, two of which are sexually transmitted, affect tens of millions of Americans and hundreds of millions of people worldwide every year. [23] However, more recent evaluations by subject matter experts do not support this rating. [28] More specifically, the EPA conducted down-the-drain estimates of the amount of lindane reaching public water supplies from the use of lindane medications using data from California water treatment facilities, concluding that lindane levels from pharmaceutical sources were extremely low and not of concern.[5]. Do not transport with food and feedstuffs. 0000002858 00000 n At the same time, a boxed warning was added to the prescription label to highlight to healthcare providers appropriate use criteria and rare treatment risks. Routes of exposure The MARINE POLLUTANT mark must conform to the following: (1) Except for size, the MARINE POLLUTANT mark must appear as follows: (2) The marking must be in the form of a square-on-point. Access to page content (press "Enter") Lindane and Formula: C6H6Cl6 Lindane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABAA receptor-chloride channel complex at the picrotoxin binding site. [13], The State of California banned the pharmaceutical use of lindane, effective 2002. 1997-2023 LUMITOS AG, All rights reserved, https://www.chemeurope.com/en/encyclopedia/Lindane.html, Your browser is not current. [1] Adverse hematologic effects have also been reported with chronic occupational exposures and excessive dermal applications; however, a direct cause and effect has not been established. The company seeks damages and injunctive relief against all of the defendants. (4) On a package of limited quantity material marked in accordance with 172.315 of this part. (d) The MARINE POLLUTANT mark is not required -. Methods for measurement of sediment, surface water, and porewater toxicity in marine environments include the sea urchin (Arbacia punctulata) fertilization and embryological development tests and copepod It is of particular concern because of %PDF-1.4 % Refer for medical attention. (4) For domestic transportation, a packaging marked prior to January 1, 2017 and in conformance with the requirements of this paragraph in effect on December 31, 2014, may continue in service until the end of its useful life. Lindane (-BHC) is an organochlorine insecticide that is classified as a persistent organic pollutant (POP), and serious health problems can arise after Lindane has been used in the U.S. for more than 60 years, both in healthcare and in agriculture. WebInternational initiatives on Lindane include the Protocol on Persistent Organic Pollutants of the Convention on Long Range Transboundary Air Pollution; the Rotterdam Convention; the OSPAR Commission for the Protection of the Marine Environment of the Northeast Atlantic, the Great Vlkov and Hofman demonstrated that soil properties affect the bioavailability of persistent organic pollutants such as lindane, DDT, phenanthrene and [18], Canadas Pest Management Regulatory Agency phased out of all agricultural uses of lindane between 2000 and 2005 due to concerns of chronic occupational exposure and risks to workers during seed treatment and planting. DEA methoxycinnamate. That's what the Environmental Protection Agency said after downgrading ozone standards in the (c) A transport vehicle or freight container that contains a package subject to the marking requirements of paragraph (a) or (b) of this section must be marked with the MARINE POLLUTANT mark. WebLINDANE: ICSC: 0053 (November 2016) gamma-1,2,3,4,5,6-Hexachlorocyclohexane gamma-BHC gamma-HCH: CAS #: 58-89-9: UN #: 2761 EC Number: 200-401-2 ACUTE For example, a meta-analysis of studies looking at the association between occupational exposure to agricultural lindane and non-Hodgkins lymphona among U.S. farmers found that lindane was not a primary factor in the development of the disease. FDA-approved for the second-line treatment of scabies, pubic lice (crabs) and head lice. 0000001466 00000 n In 2001, the Environmental Protection Agencys Cancer Assessment Review Committee for lindane downgraded the carcinogenic classification of lindane from possible to suggestive evidence, concluding that the data did not support the need for further study of the carcinogenic risks in humans. [30][31]The US FDA continues to maintain that lindane medications have necessary health benefits that outweigh potential risks and should remain available for patients with head lice, scabies and pubic lice (crabs) who have few treatment alternatives. For these purposes, 105 fish were exposed to different concentrations of Lindane for 96 h in 5 groups with 3 replications. Exposure to large amounts of lindane can negatively affect the nervous system, producing a range of symptoms from headache and dizziness to seizures, convulsions and more rarely death. Transportation WebLindane is considered to be highly toxic to aquatic organisms, and moderately toxic to birds and mammals. The direct causes of death for the other cases were attributed to reasons other than lindane. The most common side effects are nonserious reactions of the skin (e.g., burning, itching, dryness and rash). [7][8][9] The U.S. Centers for Disease Control and Prevention also includes lindane medications in their Sexually Transmitted Disease Treatment Guidelines as viable treatment alternatives for the management of scabies and pubic lice, consistent with the approved prescription labeling for these products. If appropriate, moisten first to prevent dusting. [24] The Joint Committee on Pesticide Residues (JMPR) of The World Health Organization and Food and Agricultural Organization of the United Nations similarly concluded in 2004 that In the absence of genotoxicity and on the basis of the weight of the evidence from the studies of carcinogenicity, JMPR has concluded that lindane is not likely to pose a carcinogenic risk to humans.[21], The production and use of lindane in agricultural (both of which have declined significantly in the last 20 years) are the primary causes of environmental contamination,[25] and levels of lindane in the environment have waned in the U.S. from 1986 through 2003, consistent with decreasing agricultural usage patterns. Depending on the degree of exposure, periodic medical examination is suggested. Vomiting. 0000006190 00000 n 0000005726 00000 n [4][5] This is not unlike other medications where the active ingredient has other non-healthcare applications. Dizziness. [16] Only rarely have seizures and even more rarely fatal reactions been reported when lindane medications were used (presumably) according to directions.[7][11][12]. Wash hands before eating. (b) Except as otherwise provided in this subchapter, a bulk packaging that contains a marine pollutant must -, (1) Be marked with the MARINE POLLUTANT mark on at least two opposing sides or two ends other than the bottom if the packaging has a capacity of less than 3,785 L (1,000 gallons). In case of fire: keep drums, etc., cool by spraying with water. 0000006227 00000 n However, a significant amount of Lindane is also found in The most common reports to the FDA were "drug ineffective," followed by convulsions, dermatitis and dizziness. Wear protective gloves when administering first aid. [3] It is presently banned in more than 50 countries, and is being considered for inclusion in the Stockholm Convention on persistent organic pollutants, which would ban its production and use worldwide. Camphor benzalkonium methosulfate. 0000000016 00000 n WebLINDANE ICSC: 0053 IMPORTANT DATA PHYSICAL STATE; APPEARANCE: ODOURLESS, WHITE CRYSTALLINE POWDER CHEMICAL DANGERS: On contact with hot surfaces or flames this substance decomposes forming toxic and corrosive fumes including phosgene and hydrogen chloride. [7][11][12] [16] (see also Pharmaceutical Uses) Indeed, most of the adverse human health effects reported for lindane have related to agricultural uses and chronic, occupational exposure of seed treatment workers to agricultural-grade lindane. 0000002475 00000 n Over time, lindane is broken down in soil, sediment and water into less harmful substances by algae, fungi and bacteria; however, the process is relatively slow and dependent on ambient environmental conditions. 0000057176 00000 n 0000001327 00000 n (e) MARINE POLLUTANT mark. Your browser does not support JavaScript. WebThis Lindane Reregistration Eligibility Decision (RED) Document replaces the earlier National Marine Fisheries Service No Observed Adverse Effect Level National Pollutant Discharge Elimination System EPA Office of Pesticide Programs Population Adjusted Dose Pesticide Analytical Method Public Document This article is based in part on the public domain US government document at FDA.gov. A medication guide, written in plain English, was also developed and is now required by law to be dispensed with every lindane prescription dispensed in the U.S. to better educate patients and caregivers on safe application technique. It has an oral LD50 of 88 mg/kg in rats and a dermal LD50 of 1000 mg/kg. %PDF-1.6 % A marking in conformance with the requirements of this paragraph in effect on December 31, 2014, may continue to be used until December 31, 2016. Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance, chemical protection suit including self-contained breathing apparatus and protective gloves. [6] Mexico has committed to a structured, voluntary phase out of lindane through the North American Regional Action Plan (NARAP) but currently authorizes agricultural, veterinary and healthcare uses. [4] There is a bill in the New York State Assembly and Senate to ban its use in head lice products and limit its use on scabies, which had not passed as of September 2007. [25] In 2002, the EPA concluded that lindane agricultural products were eligible for re-registration given industry compliance with certain data and labeling requirements to mitigate occupational risks to workers. [10] (see also Pharmaceutical Uses) Other countries, like Canada, similarly approve of pharmaceutical applications for lindane but no longer permit its broader use agriculturally. Well closed. It is highly toxic to fish and honeybees and moderately toxic to most To explore the toxic effects of lindane and the underlying mechanisms of this toxicity, the animal model Caenorhabditis (i) At least 100 mm (3.9 inches) as measured from the outside of the lines forming the border for marks applied to: (A) Non-bulk packages, except in the case of packages which, because of their size, can only bear smaller marks. The International HCH and Pesticide Forum has since been established to bring together experts to address the clean-up and containment of these sites. [1] Vomiting and nausea are usual symptoms associated with oral ingestions of lindane but serious neurologic effects can occur, albeit less frequently. [4][25] The latter includes the U.S. and Canada, which support public health uses of pharmaceutical lindane but no longer allow agricultural applications.

Spring Fling 2022 Mobile Alabama, Stranger Things Fanfiction Max Crying, Articles I

is lindane a severe marine pollutant